A Case of Anaphylactic Shock Due to Impurities in a Generic Drug

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  • Tanizaki Hideaki
    Department of Dermatology, Kyoto University Graduate School of Medicine
  • Kambe Naotomo
    Department of Dermatology, Kyoto University Graduate School of Medicine
  • Taki Reiko
    Department of Dermatology, Kyoto University Graduate School of Medicine
  • Matsumura Yumi
    Department of Dermatology, Kyoto University Graduate School of Medicine
  • Kore-eda Tetsu
    Department of Dermatology, Kyoto University Graduate School of Medicine
  • Toichi Eiko
    Department of Dermatology, National Hospital Organization Kyoto Medical Center
  • Miyachi Yoshiki
    Department of Dermatology, Kyoto University Graduate School of Medicine

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Other Title
  • セファゾリンナトリウムのジェネリック医薬品に含まれる類縁物質が原因と考えられるアナフィラキシーショックの1例
  • セファゾリン ナトリウム ノ ジェネリック イヤクヒン ニ フクマレル ルイエン ブッシツ ガ ゲンイン ト カンガエラレル アナフィラキシー ショック ノ 1レイ

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Abstract

A 22-year-old man, who experienced anaphylactic shock during an orthopedic operation, was referred to our hospital for allergic tests. He also had histories of allergic rhinitis due to pollen, metal allergy, and unconfortable feelings when he ate some kinds of fruit. Intradermal reaction tests revealed a positive reaction to the generic version of cefazolin sodium, but not the original drug. Both drugs have the same main ingredient without any additive, but both of them have possible impurities derived from their manufacturing process, suggesting that the impurities contaminating only the generic drug may cause an anaphylactic reaction in our present case. Today, to reduce medical expenses, generic drugs is tend to be recommended. We should pay attention not only to the costs but also to the safety information about the drugs when we prescribe them to patients.

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