Neuro-Sweet Disease: A Case Report

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  • 神経Sweet病の1例
  • シンケイ Sweetビョウ ノ 1レイ

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Abstract

We experienced a patient with Neuro-Sweet disease, a clinical entity proposed by Hisanaga et al in 2005. A 39-year-old man developed fever, sore throat, arthralgia, and painful erythematous plaques on his left arm and left eyelid. One month later, a central nerve disorder appeared; it was diagnosed as brainstem encephalitis by magnetic resonance imaging and cerebrospinal fluid study. A skin biopsy of the lesion on his eyelid demonstrated massive mature neutrophilic infiltration in the dermis without vasculitis. Human leukocyte antigen typing showed Cw1, but not B51 or B54. No ocular disorder was found. We diagnosed him with Neuro-Sweet disease. Systemic corticosteroid therapy dramatically improved his symptoms within a few weeks. Since the treatment, there has been no recurrence.

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