Theoretical study on many-body effect of interactions between nucleobases in B-DNA

DOI
  • Miyamoto Kengo
    Department of Chemistry, Graduate School of Science, Hiroshima University
  • Aida Misako
    Department of Chemistry, Graduate School of Science, Hiroshima University

Bibliographic Information

Other Title
  • B-DNAの塩基対間相互作用における多体効果についての理論化学的研究

Description

Interactions between nucleobases in DNA-duplex play an important role in biological systems. In particular, the stacking interactions and many-body effects of interactions between nucleobases depend greatly on the base sequences. Guanine (G) changes into 8-oxoguanine (8OG) after the oxidation. 8OG can take either keto or enol forms by keto-enol tautomerization. The hydrogen bonding pattern of 8OG(enol) is different from that of 8OG(keto). In other words, 8OG(enol) can pair with Thymine (T). Thus, 8OG can form 8OG(keto)-C pair and 8OG(enol)-T pair by keto-enol tautomerization. Experimentally, it has been reported that the probability of point mutation from G to A becomes higher when G changes into 8OG. In this study, we construct B-DNA model including not only Watson-Crick base pairs but also 8OG(keto)-C and 8OG(enol)-T pairs. Then, we discuss many-body effects of the interactions between nucleobases in B-DNA and the induction of point mutation from G to A.

Journal

Keywords

Details 詳細情報について

  • CRID
    1390001205736950016
  • NII Article ID
    130005146349
  • DOI
    10.11545/ciqs.2015.0_70
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

Report a problem

Back to top