A Study of the Influence of the Volume and Frequency of Application on the Efficacy of Moisturizers

Ohtani Mariko, Ohtani Michiteru, Nozawa Akane, Matsumoto Mika, Yamamura Yoshikazu, Komoda Masayo, Etoh Takafumi

doi:10.14924/dermatol.122.39

To objectively evaluate the efficacy of moisturizers with regard to differences of application volume and frequency, we examined their effects on the artificially dried skin (experimentally-induced dry skin) of healthy subjects. Heparinoid preparations (Hirudoid^® lotion or Hirudoid^® soft ointment) were applied at 0.5 mg/cm², 2 mg/cm² and 3 mg/cm² once daily in the morning or 2 mg/cm² twice daily in the morning and evening after bathing to acetone/ether-water-dried skin of the inside forearms for 14 days. The conductance of the stratum corneum was measured before the application and at 1, 2, 5, 6, 7, 8, 9, 12, 13 and 14 days after the application. With both preparations, there were no significant differences in the conductance of the stratum corneum among the application volumes. Compared with the once-daily application, the twice-daily application resulted in significantly higher conductance of the stratum corneum at almost all points of measurement in both applications. This study suggested that twice-daily application of Hirudoid preparations was more effective than oncedaily application.

A Study of the Influence of the Volume and Frequency of Application on the Efficacy of Moisturizers

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