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- Murata Yozo
- Department of Dermatology, Hyogo Cancer Center
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- Kumano Kimiko
- Department of Dermatology, Hyogo Cancer Center
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- Takai Toshihiro
- Department of Dermatology, Hyogo Cancer Center
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- Sakai Daisuke
- Department of Dermatology, Hyogo Cancer Center
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- Kikusawa Ayuko
- Department of Dermatology, Hyogo Cancer Center
Bibliographic Information
- Other Title
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- 多発性基底細胞癌は偏側性に発生する
- タハツセイ キテイ サイボウガン ワ ヘンガワセイ ニ ハッセイ スル
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Abstract
In a survey of 732 cases of basal cell carcinoma without apparent genetic or environmental background seen at Hyogo Cancer Center, 52 (7.1%) had multiple lesions. Fifteen of these developed new carcinoma metachronously. Another 37 cases had multiple carcinomas synchronously at the time of presentation and 4 of these 37 (11%) developed subsequent new carcinomas metachronously. The sites of the carcinomas were classified into three regions (head and neck, trunk, extremities) and also right or left side. The patients with 2 basal cell carcinomas in the same region tended to have tumors ipsi-laterally. A statistical analysis using the binomial test revealed that the probability of ipsi-laterality was significant (p=0.0006594). In addition, some patients had tumors in close proximity. These facts suggest the possibility of post-zygotic somatic mutation.
Journal
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- The Japanese Journal of Dermatology
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The Japanese Journal of Dermatology 122 (10), 2487-2493, 2012
Japanese Dermatological Association
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Details 詳細情報について
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- CRID
- 1390001205737956352
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- NII Article ID
- 130004714870
- 40019441774
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- NII Book ID
- AN00196602
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- ISSN
- 13468146
- 0021499X
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- NDL BIB ID
- 024000011
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed