Evaluation of Neutrophil Functions in an Individual with Pyodermia Chronica Glutealis

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  • Murayama Noriko
    Department of Dermatology, Juntendo University Urayasu Hospital
  • Iwabuchi Kazuhisa
    Department of Host Defense and Biochemical Research, Juntendo University School of Medicine
  • Someya Akimasa
    Department of Host Defense and Biochemical Research, Juntendo University School of Medicine
  • Nagaoka Isao
    Department of Host Defense and Biochemical Research, Juntendo University School of Medicine
  • Takamori Kenji
    Department of Dermatology, Juntendo University Urayasu Hospital

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  • 増悪時に好中球機能亢進が認められた臀部慢性膿皮症（汎発型）の1例
  • ゾウアクジ ニ コウチュウキュウ キノウ コウシン ガ ミトメラレタ デンブ マンセイ ノウ ヒショウ(ハンハツガタ)ノ 1レイ

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Abstract

Pyodermia chronica glutealis (PCG) is characterized by recurrent infections, and its pathogenesis has not been clarified. In this study, to evaluate the functions of neutophils in PCG, we examined superoxide (O2–) generating activity, phagocytosis and chemotaxis of neutrophils in an individual with PCG during exacerbation and remission periods. The results revealed that O2– generation by fMLP, PMA and opsonized zymosan (OZ) was enhanced during exacerbation period. During the remission period, O2– generation by PMA and OZ was returned to normal control levels ; however, O2– generation by fMLP was markedly reduced compared with that of normal controls. In addition, phagocytosis of OZ was increased during exacerbation period and returned to control levels during the remission period. In contrast, chemotactic activity for C5a did not change during the exacerbation and remission periods, and remained the same as that of normal controls. Together, these observations indicate that, in PCG, neutrophil functions are enhanced during the exacerbation period and return to the control levels during remission periods.

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