Stratum Corneum Lipid Abnormalities in the Skin of a Patient with Senile Xerosis

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  • 老人性乾皮症患者における角層細胞外脂質の量的・質的変化の検討
  • ロウジンセイ カンピショウ カンジャ ニ オケル カクソウ サイボウ ガイ シシツ ノ リョウテキ ・ シツテキ ヘンカ ノ ケントウ

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Stratum corneum (SC) lipids were extracted from the skin of a patient of senile xerosis, and the lipids were analyzed and compared with those of the young and age matched skin. The extracted lipids were purified by DEAE A25 column chromatography (acetate form) by separating the neutral and acidic fractions. The neutral fractions contained cholesterol, cholesterol esters, and ceramides 1 to 7, which were analyzed by thin-layer chromatography, and the contents were estimated by a densitometric method. In the patient SC, the contents of ceramide 2 and ceramide 7 were increased while that of cholesterol esters and ceramide 6 were significantly decreased. The acidic fraction contained free ω-hydroxy fatty acids as well as α-hydroxy fatty acids in addition to the several saturated and unsaturated fatty acids. The spectra obtained by the positive ion mass/mass spectrometry revealed that chain lengths of the free ω-hydroxy fatty acids were very long, C30 and C32 : 1. The lipid abnormalities in the patients with senile xerosis were different from those of aged skin, suggesting that the different biochemical events may occur in senile xerosis.

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