A Case of Leukemia Cutis in an Infant Presenting with a Subcutaneous Tumor

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  • 皮下腫瘤が初発症状となり診断された乳児白血病の1例
  • ヒカ シュリュウ ガ ショハツ ショウジョウ ト ナリ シンダン サレタ ニュウジ ハッケツビョウ ノ 1レイ

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Abstract

A 4-month-old girl was afflicted with a dome-shaped subcutaneous tumor of about 2 cm in diameter protruding below the left eyelid. The tumor first appeared at about 2.5 months after birth. At initial presentation, a reddish-brown infiltration containing numerous nodules was observed on the patient’s chest and abdomen. The skin biopsy revealed uniform dense infiltration of atypical mononuclear cells in the dermis and subcutaneous tissue. A bone marrow puncture esfablished a diagnosis of acute monoblastic leukemia (M5a by FAB classification). Although the skin symptoms disappeared about one week after the introduction of chemotherapy, the disease was complicated by infection and DIC, and the patient died two months after the initial diagnosis. We review other case reports of leukemia cutis in infants in Japan.

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