A Case of Drug Induced Granulomatous Reaction by Leuprorelin Acetate for Prostate Cancer

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  • Mizoguchi Kyoko
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences Course of Medical and Dental Sciences
  • Hamasaki Youichiro
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences Course of Medical and Dental Sciences
  • Katayama Ichiro
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences Course of Medical and Dental Sciences
  • Igawa Tsukasa
    Department of Urology, Nagasaki University Graduate School of Biomedical Sciences Course of Medical and Dental Sciences

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Other Title
  • 酢酸リュープロレリン（3カ月持続徐放性製剤）により生じた肉芽腫の1例―1ヵ月製剤から3ヵ月製剤へ転換すると，著明に増悪した例―
  • サクサン リュープロレリン(3カゲツ ジゾクジョホウセイ セイザイ)ニ ヨリ ショウジタ ニクガシュ ノ 1レイ : 1カゲツ セイザイ カラ 3カゲツ セイザイ エ テンカン スル ト,チョメイ ニ ゾウアク シタ レイ

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Abstract

A 73-year-old man visited our outpatient clinic with active indurated ulcer on his left abdomen. He had been medicated with luteinizing hormone releasing hormone analog for prostate cancer by subcutaneous injections of leuprorelin acetate once a month since August of 2000. In November of 2002, the leuprorelin acetate dosage was changed to a once a three month type drug. Local erythema and induration developed at the injection site after the first injection. Three months later, he developed induration and an ulcer with leakage after the second injection. The biopsied specimen revealed epithelioid cells and giant cells collected together to form a granuloma. For the final diagnosis, we performed an intradermal test with leuprorelin acetate. A positive allergic granulomatous reaction was induced by leuprorelin acetate in this case.

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