CLINICAL STUDY FOCUSED ON THE HISTOPATHOLOGICAL EXAMINATION OF COMBINATION TREATMENT INVOLVING ARTIFICIAL DERMIS AND BASIC FIBROBLAST GROWTH FACTOR FOR CONTRACTION OF SKIN DEFECTS

ITO Nao, MITSUKAWA Nobuyuki, HIGAKI Koichi, YOSHIMOTO Shinya

doi:10.14930/jshowaunivsoc.73.1

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Other Title

皮膚欠損創に対する人工真皮と塩基性線維芽細胞増殖因子製剤併用療法の創収縮における病理組織学的検討
皮膚欠損創に対する人工真皮と塩基性線維芽細胞増殖因子製剤併用療法の創収縮における病理組織学的検討 : 塩基性線維芽細胞増殖因子の瘢痕拘縮抑制効果について
ヒフケッソンソウニタイスルジンコウシンピトエンキセイセンイガサイボウゾウショクインシセイザイヘイヨウリョウホウノソウシュウシュクニオケルビョウリソシキガクテキケントウ : エンキセイセンイガサイボウゾウショクインシノハンコンコウシュクヨクセイコウカニツイテ
—塩基性線維芽細胞増殖因子の瘢痕拘縮抑制効果について—

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Abstract

Background: In recent studies, basic fibroblast growth factor (bFGF) not only promotes wound repair but also inhibits scar from contraction. This study examined a combination of artificial dermis and bFGF to treat skin defects in clinical cases and also immunohistochemically examined the effects on the conditions of recipient beds. The subjects were 10 patients with skin defects from burn ulcers or traumatic ulcers. In each subject, debridement was performed and subsequently artificial dermis was applied to the defect. The bFGF was used on one side (combination therapy side) of the artificial dermis and not used on the other side (artificial dermis monotherapy side). An immunohistochemical examination (α-Smooth Muscle Actin) was performed on the granulation tissue collected from the recipient bed approximately 2 weeks after the application of the artificial dermis. The combination therapy side had fewer α-SMA positive cells than monotherapy side (p = 0.0236). Our results show that α-SMA positive cells decreased due to the effects of the bFGF. Thus, the results suggest that this combination therapy inhibits scar from contraction in clinical cases.

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Journal of The Showa University Society

Journal of The Showa University Society 73 (1), 1-7, 2013

The Showa University Society

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