Evaluation of the reagent from the LATEX H-FABP KIT (YAMASA) for the quantitative measurement of H-FABP

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  • SHIMAZAKI Tomoyuki
    Department of Clinical Laboratory Medicine, Shinshu University Hospital
  • KAWASAKI Kenji
    Department of Clinical Laboratory Medicine, Shinshu University Hospital
  • ISHIMINE Nau
    Department of Clinical Laboratory Medicine, Shinshu University Hospital
  • IDE Norifumi
    Department of Clinical Laboratory Medicine, Shinshu University Hospital
  • SUGANO Mitutoshi
    Department of Clinical Laboratory Medicine, Shinshu University Hospital
  • HONDA Takayuki
    Department of Clinical Laboratory Medicine, Shinshu University Hospital

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Other Title
  • ラテックスH-FABPキット「ヤマサ」の基礎的性能評価

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Heart-type fatty acid-binding protein (H-FABP) is an early marker of acute coronary syndrome (ACS). Immunochromatography is a widely used method for the measurement of H-FABP. However, this method is restricted by individual differences owing to visual judgment, and only a qualitative judgment is possible. Therefore, we evaluated the reagent from the LATEX H-FABP KIT (YAMASA) for the quantitative measurement of H-FABP. This reagent had a favorable within-run precision coefficient of variation (CV) in the range of 0.65–3.98% and between-day precision CV in the range of 1.28–5.57%. Additionally, coexisting materials had no effect on the reaction. In ACS patients, the sensitivity and specificity were 72% and 59%, respectively. However, it was considered desirable to consider the time for obtaining a blood sample from a heart attack victim.

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