Formulation Study of Mohs Paste for Chemosurgery

DOI 2 Citations
  • Yamamoto Hiromitsu
    Laboratory of Pharmaceutical Engineering, Aichi Gakuin University
  • Kobayashia Mari
    Laboratory of Pharmaceutical Engineering, Aichi Gakuin University
  • Haga Rinako
    Laboratory of Pharmaceutical Engineering, Aichi Gakuin University
  • Ito Nahomi
    Laboratory of Pharmaceutical Engineering, Aichi Gakuin University
  • Ogawa Noriko
    Laboratory of Pharmaceutical Engineering, Aichi Gakuin University
  • Taguchi Maho
    Center for Clinical Pharmacy, Yokohama University of Pharmacy
  • Takahashi Chisato
    Laboratory of Pharmaceutical Engineering, Aichi Gakuin University
  • Isobe Takashi
    Laboratory of Clinical Pharmaceutics, Yokohama University of Pharmacy
  • Hanioka Nobumitsu
    Laboratory of Biochemical Toxicology, Yokohama University of Pharmacy
  • Murata Mikio
    Laboratory of Pharmaceutics, Yokohama University of Pharmacy
  • Okada Kenji
    Laboratory of Clinical Pharmaceutics, Yokohama University of Pharmacy
  • Shigeyama Masato
    Laboratory of Clinical Pharmaceutics, Yokohama University of Pharmacy

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Other Title
  • がん切除手術に用いられるMohsペーストに関する製剤学的研究

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Abstract

Mohs paste is using for chemosurgery to treat local recurrence of breast cancer tumors and other tumors. However, physicochemical properties of Mohs paste such as hardness, viscosity, stickiness, and spreadability, change signifi cantly during storage after preparation. We investigated the mechanism of change in these physicochemical properties and reformulated Mohs paste. Mohs paste was very hard immediately after preparation and then gradually became soft and sticky during storage. We found that starch particles in the formulation caused the change in physicochemical properties. The initial hardening of the paste was caused by water adsorption and swelling of starch granules. The ensuing softening and tackifying were caused by gelatinization of the starch. The change in physicochemical properties could be restricted by reduction of free water in the formulation by adding a sugar alcohol. Sorbitol was the most effective material among additives because sorbitol can interact strongly with hydration water.

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