TRANSIENT GLOBAL AMNESIA

MIZUMA Keita, YANO Satoshi, MURAKAMI Hidetomo, KAWAMURA Mitsuru, YAMAGISHI Keiko, KURIKI Ayako

doi:10.14930/jshowaunivsoc.75.191

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Other Title

一過性全健忘の病態機序
一過性全健忘の病態機序 : 12例の画像所見からの検討
イッカセイゼンケンボウノビョウタイキジョ : 12レイノガゾウショケンカラノケントウ
―12例の画像所見からの検討―
―12 CASE STUDIES―

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Description

Transient global amnesia （TGA） is a sudden and severe anterograde memory disturbance accompanied by various degrees of retrograde amnesia, not fully oriented in space and time. Characteristic punctate high-signal intensity lesions in the hippocampus CA1 on diffusion-weighted imaging （DWI） have been reported. Otherwise the pathology is not clear. We investigated the influence of the timing of DWI and considered its pathology. Patients diagnosed with TGA underwent DWI. They were divided into three subgroups according to the time lapse after the symptom onset to the first DWI （0-24 h, 24-72 h, and ＞72 h）. Between January 2009 and July 2014, 33 patients with TGA were identified and 12 underwent MRI. Of these 12 patients, 8 showed hippocampas CA1 punctuate highintensities within 24 hours. Of these ten were within 24-72 h, and one at 72 h. Seven patients had reversible hippocampal punctuate high intensities. Most DWI lesions were detectable 24 h-72 h after the onset of symptoms. Selective vulnerability of CA1 neurons to Cortical Spreading Depression and metabolic stress may play a role in the pathophysiology of TGA.

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Journal of The Showa University Society

Journal of The Showa University Society 75 (2), 191-197, 2015

The Showa University Society

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