Basic evaluation of cephem antimicrobial-induced AmpC β-lactamase overproduction by extended-spectrum β-lactamase nonproducing bacteria

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  • ESBLs非産生菌におけるAmpC型β-lactamases過剰産生を誘導するセフェム系抗菌薬の基礎的検討

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<p>A basic evaluation to determine whether AmpC production could be detected was performed using a wide variety of cephem antimicrobial agents. Results of the antimicrobial sensitivity tests for the detection of AmpC-producing organisms revealed that among the cephem antimicrobial agents evaluated, the detection was superior for CFDN, CDTR, CFPN, and CPDX. Double-inhibition zones affecting the results of the disk diffusion assay formed depending on the type of drug, and this trend was pronounced for cephamycins and oxacephems (10.3–20.7%) and also observed for third-generation cephalosporin antimicrobial agents (0–13.8%). The frequency of the formation of double-inhibition zones was relatively stable (3.4%) for CPDX, the drug used in the AmpC production test. The disk diffusion susceptibility tests performed using colonies harvested from the margins of the inhibition zones formed by strains proven to form double-inhibition zones showed that many of the strains formed smaller inhibition zones. Furthermore, many of these strains did not form double-inhibition zones, and therefore, these observations suggest enhanced AmpC production.</p>

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