Effect of testosterone replacement on bone mineral density in adolescent male hypogonadism

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  • ARISAKA OSAMU
    Department of Pediatrics, Juntendo University School of Medicine
  • HOSAKA ATSUTO
    Department of Pediatrics, Juntendo University School of Medicine
  • ARISAKA MADOKA
    Department of Pediatrics, Juntendo University School of Medicine
  • SHIMURA NAOTO
    Department of Pediatrics, Juntendo University School of Medicine
  • TOKITA AKIFUMI
    Department of Pediatrics, Juntendo University School of Medicine
  • YABUTA KEIJIRO
    Department of Pediatrics, Juntendo University School of Medicine

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Other Title
  • 男子性腺機能低下症におけるテストステロン補充の骨塩量に及ぼす影響

Description

To assess the effect of gonadal steroid replacement on bone mineral density in 10 adolescent males with osteopenia due to hypogonadism, we compared the changes in bone density in patients given testosterone (T) replacemant (n = 4) with those in patients without T replacement (n=6). Nine of the 10 patients initially had open epiphyses and received T (125mg, i.m.) every months for 12 months. Cortical bone density in the nondominant distal radius was measured by single-photon absorptiometry, which revealed that in all T-replaced patients, bone density was significantly increased (p<0.05). Among the patients without T replacement, the bone density was slightly increased in 2, but in the remaining 4, bone density did not increase. The serum osteocalcin level, measured as a biochemical marker of bone formation, was significantly increased (p<0.05) in T-replaced patients, but the corresponding change in patients without T-replacement was variable. We conclude that it is possible to increase cortical bone mineral density by testosterone replacement in men with hypogonadism, particularly those who are skeletally immature.

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