Epidemiology of <i>Helicobacter pylori</i> and stomach cancer in Japan

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  • KIKUCHI SHOGO
    Department of Public Health, Aichi Medical University School of Medicine

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  • わが国における<i>Helfcobacter pylori</i>の疫学と胃がん

Abstract

In Japan the seroprevalence of Helicobacter pylori increases with age and most infections of H. pylori are expected to occur during childhood. Large sibship size and a family history of gastric diseases are positively, and smoking and drinking habits are negatively related with seroprevalence. Infection elevates serum pepsinogen I and II, and reduces pepsinogen I to II ratio (PG I/II). Over a 7-year span, patients infected with H. pylori showed a higher frequency of PG I/II decline than those not infected. Both epidemiological evidence and experimental studies using Mongolian gerbil have provided supportive evidence on the causal relationship between H. pylori and stomach cancer, and the eradication of H. pylori is considered to prevent stomach cancer. The eradication may provoke both the decline of the occurrence of stomach cancer and an increase of cardia cancer or adenocarcinoma of the esophagus, and the frequency of the increase may not be as large as that of the decline.

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