Investigation of Mass Screening for Congenital Biliary Atresia Using the Dried Urine Spot (That is Maild in)

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  • 尿浸染濾紙による先天性胆道閉鎖症のマス-スクリーニングの検討

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Abstract

To examine the system by mail in the mass screening for congenital biliary atresia (CBA) using the dried urine spot (DUS), bilirubin in the DUS of the about one-month-old babies was measured by (the Harrison spot) test. The results were as follows. 1. DUS samples sent back between April 1, 1984 and May 14, 1985 totalled 983, and the rate of withdrawal was 54.3%. 2. Cases reported as jaundice (+) totalled 78 (7.9%). 3. Those reported as gray stool (+) (Acholic stool) accounted for 18 (1.8%). All these samples represented errors in reporting. 4. The positive reaction of bilirubin in the DUS was recognized in only one sample of stool mixed with urine. The other 982 showed the negative reaction. 5. The time elapsed before the DUS was sent back to the our institution after urine blotting in 100 cases was from one to 12 days. The average of this period was 3.85 days. The Harrison test for the detection of bilirubin in the DUS is cheap, simple and safe and facilitates detection of bilirubinemia in the baby with CBA. However, it is necessary to shorten the period between urine blotting and sending back the DUS. This method may be useful for screening for cholestatic diseases at one-month well-baby clinics, too.

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