A Pathomorphological Study on the Spongiosa of Vertebral Bones in Chronic Metabolic Disorders of Human Autopsy Cases and Experimental Animals.

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  • ODANI YOSHIHARU
    Second Departmen of Pathology, Juntendo University School of Medicine

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  • 慢性代謝障害性疾患における椎骨海綿質の病理学的変化について
  • 慢性代謝障害性疾患における椎骨海綿質の病理学的変化について-2-四塩化炭素およびコーチゾン投与,ならびに吉田肉腫接種の実験動物における組織計測的研究
  • マンセイ タイシャ ショウガイセイ シッカン ニ オケル ツイコツ カイメンシツ ノ ビョウリガクテキ ヘンカ ニ ツイテ-2-シエンカ タンソ オヨビ コーチゾン トウヨ,ナラビニ ヨシダ ニクシュ セッシュ ノ ジッケン ドウブツ ニ オケル ソシキ ケイソクテキ ケンキュウ
  • Part 2. A Histometrical Study on Experimental Animals Injected Carbon Tetrachloride and Cortisone Acetate, and Inoculated Yoshida Sarcoma
  • 第2報 四塩化炭素およびコーチゾン投与, ならびに吉田肉腫接腫の実験動物における組織計測的研究

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Changes of trabecular bone spicules of the 3rd lumbar vertebral spongiosa are investigated morphologically and histometrically in human autopsy cases and in experimental animals. A histological and histometrical study on the spongiosa of lumbar vertebrae of autopsy cases of liver cirrhosis, hepatomas and gastric cancers showed marked reduction in the volume percentage of trabecular bone spicules corresponding their somewhat peculiar morphological patterns (Part 1). In this report, the author designed 3 biological experiments which will show similar effects on the vertebral bone spicules. In a histometrical study, volume percentage, and absolute area and absolute length of circumference and maximum of one spiculum are measured.using a quantitative picture analyse system (BX-1; Muto Kogyo Co., Ltd.). Results : A). Repeated subcutaneous injections of carbon tetrachloride in the series of Sprague-Dawley rats for 9 weeks showed marked reduction in the volume percentage in absolute areas and in absolute lengths of circumference and in maximum of trabecular bone spicules of lumbar vertebrae spongiosa. These results are almost identical with analogical morphological patterns in the human chronic metabolic disorders. B). Repeated subcutaneous injections of cortisone acetate in the series of Sprague-Dawley rats for 7 weeks and in rabbits for 6 weeks showed almost equal patterns as that of experiment A. C). One shot intraperitoneal inoculation of the Yoshida Sarcoma cells in the series of Donryu rats showed marked coincidence with above-mentioned A and B experiments. Conclusion : In a histological and histometrical study marked reduction in volume percentage and in absolute length of circumference and maximum of trabecular bone spicules of the vertebral spongiosa and changes of bone loss of morphological patterns are found in series of three experiments such as, repeated subcutaneous injections of carbon tetrachloride and cortisone acetate in rats and/or rabbits, and one shot inoculation of Yoshida Sarcoma cells in rats. These changes were analogous to that of human autopsy cases.

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