A CLINICOPATHOLOGICAL STUDY OF 32 CASES OF APOCRINE CARCINOMA OF THE BREAST

DOI Web Site Web Site 61 References
  • ABE IKUKO
    DEPARTMENT OF BREAST AND ENDOCRINE SURGERY, JUNTENDO UNIVERSITY FACULTY OF MEDICINE
  • ARAKAWA ATSUSHI
    DEPARTMENT OF HUMAN PATHOLOGY, JUNTENDO UNIVERSITY FACULTY OF MEDICINE
  • YASUDA JUN
    BREAST CENTER, JUNTENDO UNIVERSITY
  • TOMIYAMA SATOKO
    DEPARTMENT OF BREAST AND ENDOCRINE SURGERY, JUNTENDO UNIVERSITY FACULTY OF MEDICINE
  • SAITO MITSUE
    DEPARTMENT OF BREAST AND ENDOCRINE SURGERY, JUNTENDO UNIVERSITY FACULTY OF MEDICINE
  • KASUMI FUJIO
    DEPARTMENT OF BREAST AND ENDOCRINE SURGERY, JUNTENDO UNIVERSITY FACULTY OF MEDICINE

Bibliographic Information

Other Title
  • 乳腺アポクリン癌32例の臨床病理学的検討
  • ニュウセン アポクリンガン 32レイ ノ リンショウ ビョウリガクテキ ケントウ

Search this article

Abstract

Objective : We investigated 32 patients (34 lesions) with apocrine carcinoma (AC) of the breast for estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (Her2), and Ki67 expression. We analyzed the histological features of AC and their contribution to the diagnosis and treatment of AC. Materials : Thirty-two patients with histopathologically confirmed AC (two bilateral, 34 lesions in total) were identified among 1,910 primary breast cancer patients at the Department of Breast and Endocrine Surgery, Juntendo University School of Medicine, between January, 2006 and December, 2010. Methods : Optical microscopic study, immunohistological study, and ultrasonographic study were conducted. Results : Four patients with lymph node metastasis had invasive carcinoma : 1 was AC with ductal carcinoma, and 3 were AC without ductal carcinoma. These 4 patients were strongly positive for Ki67 according to the Ki67 labeling index (LI). According to the intrinsic subtype classification, 1 lesion was classified as Luminal A, 4 were Her2-negative and Luminal B, 1 was Her2-positive and Luminal B, 7 were Her2-rich, and 21 were triple-negative lesions. Among the 12 AC lesions found to be complicated by ductal carcinoma, 1/1 was Luminal A, 2/7 were Her2-rich, and 9/21 were triple-negative. Meanwhile, 5 of the 12 AC lesions complicated by ductal carcinoma were strongly positive for Ki67 LI. Conclusions : Three patients with invasive AC without ductal carcinoma in the present study had lymph node metastasis. These 3 patients tended to have relatively high Ki67 LI values, indicating that they may have had a high latent malignancy. Patients with this type of lesion may require more careful postoperative follow-up in the future, and treatment with conventional treatments, such as chemotherapy and hormone therapy, is recommended.

Journal

References(61)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top