The modulation of auditory evoked responses by intratympanic dexamethasone in an acoustic exposure model

YOKOI NAOKO, ISHIKAWA MASAHARU, KANO AKIKO, YOSHIKAWA HIROSHI, ICHIKAWA GINICHIRO

doi:10.14789/pjmj.49.185

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Other Title

急性音響外傷モデルにおけるデキサメタゾン鼓室内投与による聴性誘発反応の変化
キュウセイオンキョウガイショウモデルニオケルデキサメタゾンコシツナイトウヨニヨルチョウセイユウハツハンノウノヘンカ

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Objective : To study changes with time in auditory evoked responses with intratympanic dexamethasone administration after an acoustic exposure. Materials : Guinea pigs with normal Preyer's reflex. Methods : Tracheostomy was performed under general anesthesia, a muscle relaxant was administered and experiments were conducted under artificial ventilation. For acoustic exposure, 105dBSPL, 4kHz pure tone was given for 30 minutes. After exposure, dexamethasone was administered intratympanically and withdrawn 10 minutes later. As the control, a saline solution was administered on the opposite side. Wave I of ABR and CAP were evaluated before exposure, immediately after exposure, immediately after drug administration, and 1 hour and 2 hours after the exposure. Results : In the present experiment, no significant differences in latency or amplitude were found between the dexamathasone administration side and the control side. However, when latency of ABR I wave and that of CAP were studied in each individual, the recovery of latency was seen more frequently on the dexamathasone administration side in many animals.

Journal

Juntendo Medical Journal

Juntendo Medical Journal 49 (2), 185-193, 2003

The Juntendo Medical Society

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