Updating of Fear Memories by Behavioral Interventions during Memory Reconsolidation
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- Nitta Yusuke
- Graduate School of Human Sciences, Waseda University
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- Takahashi Toru
- Graduate School of Human Sciences, Waseda University
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- Kumano Hiroaki
- Faculty of Human Sciences, Waseda University
Bibliographic Information
- Other Title
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- 記憶再固定化進行中の行動的介入による恐怖記憶のアップデート
- キオク サイコテイカ シンコウ チュウ ノ コウドウテキ カイニュウ ニ ヨル キョウフ キオク ノ アップデート
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Abstract
<p>Extinction training establishes extinction learning and, thus, inhibits conditioned fear responses. However, fear responses may return because extinction learning cannot affect memory trace that is the origin of fear. Exposure therapy, which is based on the extinction learning paradigm, is used to treat anxiety disorders. Relapses of anxiety disorders after exposure therapy have also been reported. Consequently, treatments, which can prevent the return of fear responses, are needed. Recently, a mechanism known as memory reconsolidation has been receiving much attention. Consolidated memory traces are destabilized after they have been retrieved. Those memory traces are stabilized again by means of the reconsolidation process. During reconsolidation, retrieved fear memory can be updated. Furthermore, recent studies have shown that extinction training during reconsolidation updates fear memory and prevents the return of fear responses. Further studies are required to determine the effects of reconsolidation interventions on anxiety disorders.</p>
Journal
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- Anxiety Disorder Research
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Anxiety Disorder Research 8 (1), 58-66, 2016
Japanese Society of Anxiety Disorder
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Details 詳細情報について
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- CRID
- 1390001205758413440
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- NII Article ID
- 130005239999
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- NII Book ID
- AA12761156
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- ISSN
- 21887586
- 21887578
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- NDL BIB ID
- 029640738
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed