書誌事項
- タイトル別名
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- Plasma and Urinary Levels of Vitamin C after Oral Administration of Calcium Ascorbate Preparation
- アスコルビンサン カルシウム オ ハイゴウ シタ セイザイ オ ケイコウ トウ
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説明
We have examined the plasma and urinary levels of vitamin C after oral administration of calcium ascorbate preparation in six healthy males(20〜27 years). They were given a preparation A or B in a two-period crossover trial. A contains 363 mg of calcium ascorbate and 700 mg of ascorbic acid, and B contains 1000 mg of ascorbic acid. The mean plasma concentration of vitamin C at 1 and 2 h was lower (p < 0.05), but was higher (p < 0.05) at 6 and 9 h in A than that in B. Truax was 3 h for both preparations. The mean Cmax (mg/100 ml, above the initial value) was 1.11 for A and 1.09 for B. The mean AUC_<0-24>(mg・h/100 ml)was 10.57 for A and 10.13 for B. The MRT_<0-24> (h) for A was 8.20 compared to 7.82 for B (p<0.05>). The MRT_<0-∞>(h) was 15.21 and 14.68 for A and B, respectively. The mean amount of vitamin C (mg, above the initial value) excreted in urine during the 0-3 h was 38 for A and 53 for B (p<0.05). During 3-6 h it was 133 and 122 (p<0.05) for A and B, respectively. The percentage of the dose excreted during the 0-24 h was essentially the same: 27.0 % for A and 26.7 % for B. The mean urinary excretion of oxalic acid (mg/24 h) following vitamin C administration was 33.7 for A and 34.8 for B, but the increase of oxalic acid was minor. In conclusion, we found that although minor differences were observed in absoption rate and residence time between A and B, calcium ascorbate and ascorbic acid show similar pharmacokinetics after oral administration.
収録刊行物
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- ビタミン
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ビタミン 72 (10), 523-529, 1998
公益社団法人 日本ビタミン学会
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詳細情報 詳細情報について
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- CRID
- 1390001205760482816
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- NII論文ID
- 110002843424
- 10018324469
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- NII書誌ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL書誌ID
- 4587345
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDLサーチ
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
