Vitamin B_<12> and Anemia : Historic Review

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  • OKUDA Kunio
    Department of Medicine, Chiba University School of Medicine

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  • ビタミンB_<12>と貧血 : その歴史の流れ
  • ビタミン B12 ト ヒンケツ ソノ レキシ ノ ナガレ

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Abstract

This review describes the historic background of the discovery of vitamin B_<12> that began with the clinical study made by Minot and Murphy who successfully treated patients with pernicious anemia by feeding large quantities of beef liver. It was followed by a series of human experiments conducted by Castle who elaborately demonstrated that hemopoiesis required an exogenous food (extrinsic) factor as well as an endogenous factor that resided in the gastric juice (intrinsic factor). Led by this hypothesis, the extrinsic factor was subsequently identified in the liver as vitamin B_<12> and the intrinsic factor as a glycoprotein produced by the parietal cells of the stomach. Based on these studies and discoveries, pernicious anemia is now an established autoimmune disease with an epitope residing in the membrane of the parietal cell.

Journal

  • VITAMINS

    VITAMINS 73 (5-6), 297-302, 1999

    THE VITAMIN SOCIETY OF JAPAN

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