書誌事項
- タイトル別名
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- Physiological Roles of Cellular Retinol-binding Protein, Type II and Regulation of Its Gene Expression in Small Intestine
- 小腸における細胞性レチノール結合タンパク質Type 2の生理的役割およびその遺伝子発現調節
- ショウチョウ ニ オケル サイボウセイ レチノール ケツゴウ タンパクシツ T
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Cellular retinol-binding protein, type II (CRBP(II)) is present in large quantities in small intestine, and may play an important role in absorption and metabolism of retinol and β-carotene. The involvement of CRBP (II) in retinol absorption and its esterification in enterocytes have been proven in our several studies. The CRBP (II) levels in the small intestine were very low in embryonic chicks and then increased rapidly around hatching. Retinol bound to CRBP (II) is esterified by lecithin : retinol acyltransferase (LRAT) which activity was also extremely low in the embryos, but rose rapidly around hatching in parallel with the induction of intestinal CRBP (II). Also CRBP (II) was evidenced its role in preventing the toxic effect of unbound retinol n the rat small intestine, suggesting that consumption of excess vitamin A in amounts below 10 times the NRC'c requirement may not cause toxic disturbance. W found that the jejunum-bypass operation led to increases in the amounts of both CRBP (II) and lipoprotein Apo-B in the residual jejunal segment, suggesting that CRBP (II) might be enhanced by high fat absorption. Indeed, we discovered that rat CRBP (II) mRNA was enhanced by high fat (corn oil) diet. This increase was due to unsaturated fatty acids, but its mRNA levels were not directly related to the expression of RXRα and peroxisome proliferator-activated receptor (PPARα). We concluded that dietary fatty acids modify the CRBP (II) gene expression.
収録刊行物
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- ビタミン
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ビタミン 71 (7), 273-283, 1997
公益社団法人 日本ビタミン学会
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詳細情報 詳細情報について
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- CRID
- 1390001205761348480
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- NII論文ID
- 110002874660
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- NII書誌ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL書誌ID
- 4268790
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可