Participation of Hepatic Cysteine Proteinases and Aminotransferase in Gluconeogenetic Pathway from Hepatic Proteins
-
- INUBUSHI Tomoko
- Institute for Health Sciences, Tokushima Bunri University
-
- SHIKIJI Michie
- Institute for Health Sciences, Tokushima Bunri University
-
- ENDO Koichi
- Institute for Health Sciences, Tokushima Bunri University
-
- KAKEGAWA Hisao
- Institute for Health Sciences, Tokushima Bunri University
-
- KISHINO Yasuo
- Department of Nutrition, School of Medicine The University of Tokushima
-
- KATUMURA Nobuhiko
- Institute for Health Sciences, Tokushima Bunri University
Bibliographic Information
- Other Title
-
- 肝タンパク質からの糖新生におけるシステインプロテアーゼ群とアミノ基転移酵素の役割
- カン タンパクシツ カラ ノ トウ シンセイ ニ オケル システインプロテアー
Search this article
Abstract
In the course of gluconeogenesis from hepatic proteins, the activities of lysosomal cysteine proteinases, such as cathepsins B, L, H and J(C) and deaminating enzymes, such as alanine aminotransferase were changed coordinately. When rats were placed on sufficient starvation, the both activities of cathepsins and aminotransferases in the liver were significantly elevated. Furthermore, the activity of hepatic cathepsin L increased markedly by glucagon treatment and insulin treatment caused marked decrease in the activities of cathepsins L and H. The changes in these cathepsin activities by the starvation or the hormone treatments may resulted in the increase of protein amounts judging from Western blotting analysis. The administration of prednisolone caused marked induction of alanine aminotransferase, however the level of hepatic cathepsins was not changed. The glucocorticoid may participate in the regulation of gluconeogenesis from amino acids digested from dietary proteins.
Journal
-
- VITAMINS
-
VITAMINS 70 (1), 23-28, 1996
THE VITAMIN SOCIETY OF JAPAN
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390001205761716480
-
- NII Article ID
- 110002845383
-
- NII Book ID
- AN00207833
-
- ISSN
- 2424080X
- 0006386X
-
- NDL BIB ID
- 3919248
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- NDL
- CiNii Articles
-
- Abstract License Flag
- Disallowed