STUDIES ON VITAMIN C METABOLISM : (III) METABOLISM OF DEHYDROASCORBIC ACID IN HUMAN SUBJECTS

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  • TERUUCHI Junya
    Department of Biochemistry, Kanagawa Prefectural College of Nutrition
  • MOCHIZUKI Hiroko
    Department of Biochemistry, Kanagawa Prefectural College of Nutrition

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Other Title
  • ビタミンCの代謝 : (III)人における酸化型ビタミンCの代謝
  • ビタミンCの代謝-3-
  • ビタミン C ノ タイシャ 3

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Description

The present experiment was designed to ascertain the availability of dehydroascorbic acid as a source of vitamin C for the human subject. Comparison of results with oral administration of dehydroascorbic acid and of ascorbic acid showed interesting differences. Solutions of dehydroascorbic acid, freshly prepared by oxidation of ascorbic acid with bromine were used. After giving equal doses of dehydroascorbic acid and ascorbic acid, equal amounts of ascorbic acid were excreted in urine, but after oral administration of dehydroascorbic acid the blood and urinary vitamin C increased more rapidly than in the case of ascorbic acid. The fact that the same dose of ascorbic acid and dehydroascorbic acid given orally leads to the excretion of similar amounts of ascorbic acid in the urine suggests that the latter is almost quantitatively reduced to ascorbic acid and is satisfactorily utilized in the body. Dehydroascorbic acid readily penetrates erythrocytes and is reduced to ascorbic acid. After adding 2.26 mg of dehydroascorbic acid to 10 ml of leucocyte-free blood, ascorbic acid content per 100 ml in plasma was 4.4 mg, and in erythrocytes 14.8 mg after 15 minutes at 37℃.

Journal

  • VITAMINS

    VITAMINS 17 (0), 385-390, 1959

    THE VITAMIN SOCIETY OF JAPAN

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