Effect of Ascorbic Acid on Aluminium Absorption and Excretion in Nephropathic Guinea Pigs
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- OKAYAMA Kazuyo
- Yokohama Sen-in Hoken Hospital
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- FUKUSHIMA Masako
- Graduate School of Nutrition, Showa Women's University
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- KUMAZAWA Yukiko
- Graduate School of Nutrition, Showa Women's University
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- SUZUE Ryokuero
- Graduate School of Nutrition, Showa Women's University
Bibliographic Information
- Other Title
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- 腎障害モルモットにおけるアルミニウムの生体内吸収蓄積に及ぼすアスコルビン酸の影響
- ジンショウガイ モルモット ニ オケル アルミニウム ノ セイタイナイ キュウシュウ チクセキ ニ オヨボス アスコルビンサン ノ エイキョウ
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Abstract
Aluminium(Al) accumulates on nervous tissue and bone, and causes unfavorable syndromes on nephropathy patients. It is well known that some organic acids accelerate aluminium absorption. So we, at first, induced nephropathy of guinea pig by giving HgCl_2, and examined the effects of ascorbic acid(AsA) on aluminium absorption and excretion. Guinea pigs were divided into 5 groups. They were low AsA+A1 group, low AsA group, high AsA+Al group, high AsA group, and control group. Except for the control group, kidneys were damaged by intaking of HgC1_2. After 7 weeks, they were sacrificed and Al contents in organs were measured by atomic absorption spectrophotometer. On bone, Al contents were extremely high in AsA administered groups. But in the control group, A1 content showed normal value.
Journal
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- VITAMINS
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VITAMINS 73 (2), 83-87, 1999
THE VITAMIN SOCIETY OF JAPAN
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Keywords
Details 詳細情報について
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- CRID
- 1390001205762545536
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- NII Article ID
- 110002843680
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- NII Book ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL BIB ID
- 4660882
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed