Two Dogs with Osteogenesis Imperfecta

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  • FURUTA Kensuke
    Yokohama-Aoba Animal Hospital, Kanagawa 224-0003, Japan Kitasato University School of Veterinary Medicine Small Animal Surjery 1, Aomori 034-8628, Japan
  • ISHII Shunji
    Kitasato University School of Veterinary Medicine Small Animal Surjery 1, Aomori 034-8628, Japan
  • ARAI Ayaka
    Kasanami Animal Hospital, Saitama 343-0025, Japan
  • OKUTOMI Saori
    Shiraishi Animal Hospital, Saitama 350-1304, Japan
  • SAKONJYU Iwao
    Kitasato University School of Veterinary Medicine Small Animal Surjery 1, Aomori 034-8628, Japan

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Other Title
  • 骨形成不全症が疑われた犬の2例
  • コツ ケイセイ フゼンショウ ガ ウタガワレタ イヌ ノ 2レイ

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Abstract

Two young dogs (a 4-month-old male French Bulldog, and a 4-month-old male Akita) presented with severe systemic pain involving bone resorption and multiple fractures. Other diseases characterized by bone fragility were excluded by clinical examinations, and so the dogs were provisionally diagnosed with osteogenesis imperfecta. In both dogs, the systemic pain resolved within 1 week after the start of diagnostic treatment with oral bisphosphonate (0.5–1.0 mg/kg), and bone unions were achieved in the multiple fractures. The two dogs have been in good physical condition without further fractures for 27 and 22 months, respectively. The definitive diagnosis of canine osteogenesis imperfecta is currently difficult because it requires genetic diagnosis. Diagnostic treatment with oral bisphosphonate is effective in alleviating potentially fatal symptoms in dogs with suspected osteogenesis imperfecta.

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