書誌事項
- タイトル別名
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- Innovation of Human Specific Disease Research Using Humanized Mouse : Complemented Research between Applied Mathematics and Experimental Medicine(<Special Topics>Mathematical Model of Disease)
- ヒト化マウスを用いたヒト特異的疾患研究のイノベーション : 応用数学と実験医学の融合
- ヒトカ マウス オ モチイタ ヒト トクイテキ シッカン ケンキュウ ノ イノベーション : オウヨウ スウガク ト ジッケン イガク ノ ユウゴウ
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抄録
Recently, in order to investigate the fundamental phenomena in immunology and virology such as maintenance of immune memory, T-cell homeostasis, the relationship between aging and immunosenescence, the regulation of the adaptive immune response during viral infection, the pathogenesis of CD4^+ depletion in HIV infection, and the underlying mechanisms of leukemia, we successfully quantied lymphocyte kinetics in humanized mice through BrdUlabeling experiment. It is worth noting that our findings are the first to assess lymphocyte dynamics utilizing this technique. At first, we will briefly give an outline of the "Quantification system of lymphocyte kinetics in humanized mice" and then we will discuss about properties of the lymphocyte kinetics and utilities of our established system.
収録刊行物
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- 応用数理
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応用数理 22 (2), 85-94, 2012
一般社団法人 日本応用数理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205765393920
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- NII論文ID
- 110009477034
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- NII書誌ID
- AN10288886
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- ISSN
- 09172270
- 24321982
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- NDL書誌ID
- 023835610
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可