THE ANTAGONISTIC ACTION OF HOMOPANTOTHENIC ACID AGAINST PANTOTHENIC ACID

DOI Web Site

Bibliographic Information

Other Title
  • ホモパントテン酸のパントテン酸拮抗作用について
  • ホモパントテンサン ノ パントテンサン キッコウ サヨウ ニ ツイテ

Search this article

Abstract

The action of homopantothenic acid, HOCH_2C(CH_3)_2CHOHCONH(CH_2)_3COOH, a derivative of γ-aminobutyric acid, and its hydroxy-forms was examined using lactobacilli and chick. These compounds showed a pronounced competitive antagonistic action for Lactobacillus arabinosus 17-5 and Leuconostoc mesenteroides P-60. When the 50% growth inhibition of homopantothenic acid was used as the index, an inhibition ratio of 150 was obtained. In the chick given 1mg/kg a day of pantothenic acid, oral administration of more than 2g/kg of homopantothenic acid induced pantothenic acid deficiency and reduction of liver CoA. These changes could be reversed by administration of pantothenic acid. This antagonistic effct of homopantothenic acid against pantothenic acid would be attributed to an inhibitory action in the pathway of biosynthesis from pantothenic acid to CoA.

Journal

  • VITAMINS

    VITAMINS 32 (2), 245-259, 1965

    THE VITAMIN SOCIETY OF JAPAN

Details 詳細情報について

Report a problem

Back to top