STUDIES ON THE PYRIMIDINE DERIVATIVES AND RELATED COMPOUNDS : (LXII) REACTIONS OF THIAMINE WITH PHOSPHONATES (4)
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- TAKAMIZAWA Akira
- Shionogi Research Laboratory
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- HAMASHIMA Yoshio
- Shionogi Research Laboratory
Bibliographic Information
- Other Title
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- ピリミジン誘導体および関連化合物の研究 : (XLII)ビタミンB_1とリン誘導体との反応(4)
- ピリミジン誘導体および関連化合物の研究-42-ビタミンB1とリン誘導体との反応-4-
- ピリミジン ユウドウタイ オヨビ カンレン カゴウブツ ノ ケンキュウ 42 ビタミン B1 ト リン ユウドウタイ ト ノ ハンノウ 4
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Abstract
Thiamine-ylide (II) obtained by the treatment of thiamine-HCl (I) with piperidine reacted with diethylbenzoylphosphonate (III) to give 1-phenyl-3-(2-hydroxy) ethyl-4,9-dimethyl-1,6-dihydropyrimido[4', 5'-4,5]pyrimido[2,3-c][1,4] thiazine (IV), IV-benzoate (V), and N-benzoylpiperidine (VI), while the reaction of morpholine treated I with III gave only small amount of IV, but N-benzoylmorpholine (VII), and 4-(2-methyl-4-amino-5-pyrimidyl) methylmorpholine (VIII) as main reaction products. It is interesting that the evidence thus obtained VIII from the above mentioned reaction offers a new progressive demonstration to previous amine substitution reactions to thiamine-thiazole nucleous in the presence of sulfite anion.
Journal
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- VITAMINS
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VITAMINS 33 (6), 661-663, 1966
THE VITAMIN SOCIETY OF JAPAN
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Details 詳細情報について
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- CRID
- 1390001205784835456
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- NII Article ID
- 110002865495
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- NII Book ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL BIB ID
- 8424126
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed