Antiangiogenic and anticancer functions of tocotrienol and its application for food products

DOI Web Site
  • Miyazawa Teruo
    New Industry Creation Hatchery Center (NICHe), Tohoku University:Graduate School of Agricultural Science (GSAS), Tohoku University

Bibliographic Information

Other Title
  • トコトリエノールの腫瘍性抗血管新生作用と食品応用に関する研究
  • トコトリエノール ノ シュヨウセイ コウケッカン シンセイ サヨウ ト ショクヒン オウヨウ ニ カンスル ケンキュウ

Search this article

Abstract

The antiangiogenic and anticancer functions of tocotrienol (an unsaturated vitamin E) were discovered, and their molecular mechanisms were clarified in studies using cell cultures and experimental animals. Tocotrienol inhibits hypoxia-induced vascular endothelial growth factor secretion, and suppresses vascular endothelial growth factor and interlukin-8 expression at both mRNA and protein levels in tumor cells. The physiological functions of tocotrienol based on its intestinal absorption, its tissue organ distribution, its skin anti-inflammation and its improved lipid metabolism were also explained. The tocotrienol-rich rice plant strain was established, and the daily intake of tocotrienol in Japanese population and the safety of dietary intake of tocotrienol were confirmed. These investigations indicate the physiological significance of tocotrienol ingestion as a fat-soluble vitamin and a functional component in food products.

Journal

  • VITAMINS

    VITAMINS 90 (2), 68-76, 2016

    THE VITAMIN SOCIETY OF JAPAN

Keywords

Details 詳細情報について

Report a problem

Back to top