Absorption, Metabolism and Antivitamin B_6 Activities of 4´-Substituted Pyridoxine Analogues
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- KAWAKAMI-DAIMON Kyoko
- Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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- MIZUNO Nobuyasu
- Faculty of Pharmaceutical Sciences, Mukogawa Women's University
Bibliographic Information
- Other Title
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- ピリドキシン4´位置換誘導体の吸収,代謝,並びにビタミンB_6拮抗作用
- ピリドキシン4′位置換誘導体の吸収,代謝,並びにビタミンB6拮抗作用
- ピリドキシン 4 イ チカン ユウドウタイ ノ キュウシュウ タイシャ ナラビ
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Description
Several 4'-substituted pyridoxine (PN) analogues were synthesized and the antivitamin B_6 activities were tested using Saccharomyces carlsbergensis and mouse. 4'-Methoxy PN (4'-MPN), 4'-ethoxy PN (4'-EPN), 4'-propoxy PN (4'-PPN) and 4'-isopropoxy PN (4'-isoPPN) showed a slight antivitamin B_6 activities for S. carls., but found to be more potent antivitamin B_6 than 4'-deoxy PN (4'-DPN) for mouse. These analogues induced the characteristic convulsions at the intraperitoneal dose of 0.05 mmol/kg, 0.08 mmol/kg, 0.20 mmol/kg and 0.44 mmol/kg, respectively. The convulsions were prevented by the administration of PN and PLP. In rats, 64% of 4'-PPN administered orally or intraperitoneally were excreted in the urine within 24 hours and 4'-PPN 3-sulfate was estimated as a metabolite in the urine.
Journal
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- VITAMINS
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VITAMINS 54 (2), 49-55, 1980
THE VITAMIN SOCIETY OF JAPAN
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Details 詳細情報について
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- CRID
- 1390001205809859712
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- NII Article ID
- 110002845278
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- NII Book ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL BIB ID
- 2210453
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed