Metabolism of 3,4´-O-Isopropylidene Pyridoxine and 4´,5-O-Isopropylidene Pyridoxine in Rats

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  • MORITA Emiko
    Faculty of Pharmaceutical Sciences, Mukogawa Women's University
  • MIZUNO Nobuyasu
    Faculty of Pharmaceutical Sciences, Mukogawa Women's University

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Other Title
  • 3,4´-O-Isopropylidene Pyridoxineと4´,5´-O-Isopropylidene Pyridoxineのラットにおける代謝
  • 3,4′-O-Isopropylidene Pyridoxineと4′,5′-O-Isopropylidene Pyridoxineのラットにおける代謝
  • 3 4 O Isopropylidene Pyridoxine ト 4 5 O

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Description

Metabolism of 3,4'-O-isopropylidene pyridoxine (3,4'-IPP) and 4',5'-O-isopropylidene pyridoxine (4',5'-IPP) was studied in rats. Following an oral or intraperitoneal administration of 3,4'-IPP, urinary excretion of pyridoxine (PN) was about 2~5% of the administered dose at mole base. About 20% of orally administered 4',5'-IPP were excreted as PN in the urine, but about 1~2% were detected as PN in the urine after an intraperitoneal injection. A metabolite of 4',5'-IPP in the urine was separated and purified by chromatographic techniques. The metabolite was assumed to be 4',5'-IPP 3-sulfate by measurement of Rf values on thin-layer chromatography and ultraviolet absorption spectra, identification of acid hydrolyzed product and detection of sulfate ion after acid hydrolysis.

Journal

  • VITAMINS

    VITAMINS 54 (3), 89-93, 1980

    THE VITAMIN SOCIETY OF JAPAN

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