Anti-inflammatory effects of Vitamin K : (II) EFFECTS OF COMBINATION WITH PREDNISOLONE

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Other Title
  • Vitamin Kの抗炎症作用 : (II)Prednisolone併用効果
  • Prednisolone併用効果
  • Prednisolone ヘイヨウ コウカ

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Description

Fekete et al. and Ibayashi et al. reported that either K_3 or K_1 enhanced the effect of prednisolone. The attempt was made to test whether K_2 enhanced the effect of prednisolone. The anti-inflammatory effect of K_2 was not influenced by adrenalectomy and did not enhanced the effect of prednisolone in rat paw edema. K_2 did not summated the inhibitory effect of prednisolone on the granuloma proliferation in cotton pellet test and K_2 was also not enhanced the effect of prednisolone in the thymus involution test. In these experiments, the effects of K_2 were similar to that of solvent and influences of solvent was thought to be important in the anti-inflammatory effect of fatty soluble compounds. From the above results, it was not shown that K_2 enhanced the effects of prednisolone. It appears to be questionable that K enhanced the effects of adrenocortical steroid hormone.

Journal

  • VITAMINS

    VITAMINS 43 (6), 299-306, 1971

    THE VITAMIN SOCIETY OF JAPAN

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