Multifunctional Activities of Lipoamide Dehydrogenase

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  • BANDO Yoshimi
    University of Tokushima, The Institute for Enzyme Research
  • AKI Kenji
    University of Tokushima, The Institute for Enzyme Research

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Other Title
  • リポ酸脱水素酵素の機能の多様性
  • リポサン ダツ スイソ コウソ ノ キノウ ノ タヨウセイ

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Description

Lipoamide dehydrogenase contains FAD and redox-acitve disulfide in its active center. The enzyme accepts two electron or four electrons under various conditions. In this paper we describe the electron transfer reaction mechanisms of NADH : lipoate reductase, NADH :osygen reductase, and NADH : menadione reductase. The enzyme catalyzed a mixed one-electron and two-electron reduction of oxygen and menadione, the two-electron transfer mechanism being dominant. The oxidase reaction is associated with fully-reduced flavin, and the menadione reductase reaction with half-reduced flavin. Furthermore, the superoxide radical generated by various reactions of the enzyme can reduce consecutively ferritin iron.

Journal

  • VITAMINS

    VITAMINS 67 (5-6), 217-223, 1993

    THE VITAMIN SOCIETY OF JAPAN

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