Effect of Dietary N^1-Methylnicotinamide or Trigonelline on the Growth and the Niacin Metabolism in Weanling Rats

DOI Web Site 5 Citations
  • SHIBATA Katsumi
    Department of Food Science and Nutrition, Teikoku Women's University
  • TAGUCHI Hiroshi
    Department of Agricultural Chemistry, Faculty of Agriculture, Mie University

Bibliographic Information

Other Title
  • N^1-メチルニコチンアミドもしくはトリゴネリンの経口投与がラットの成長およびナイアシン代謝に及ぼす影響
  • N1 メチルニコチンアミドモシクハ トリゴネリン ノ ケイコウ トウヨ ガ ラ

Search this article

Description

The conversion of N^1-methylnicotinamide (MNA) and trigonelline (TRG) to niacin and their toxicity in rats were investigated. The conversion of MNA into nicotinamide in rats did not seem to occur since the niacin effect was not observed when MNA was administered with tryptophan-imbalanced-niacin-free diet to weanling rats. When a large amount of MNA or TRG was administered to weanling rats, no growth retardation was observed. All of the TRG taken was excreted unchanged into urine. On the other hand, 10% of MNA taken was metabolized to N^1-methyl-2-pyridone-5-carboxamide and 70% of MNA was excreted unchanged. Even when a large amount of TRG or MNA was administered to rats, urinary excretion of niacin did not increase. From these results, it is concluded that the conversion of MNA and TRG into niacin does not occur and MNA and TRG are inert and very safe compounds in rats.

Journal

  • VITAMINS

    VITAMINS 61 (10), 493-499, 1987

    THE VITAMIN SOCIETY OF JAPAN

Citations (5)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top