Influence of Dietary Xenobiotics on The Metabolism of Vitamin E with Special Reference to Cholesterol Metabolism
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- KATO Norihisa
- Faculty of Applied Biological Science, Hiroshima University
Bibliographic Information
- Other Title
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- 生体異物に対するビタミンEの代謝応答 : コレステロール代謝との関連を中心として
- セイタイ イブツ ニ タイスル ビタミン E ノ タイシャ オウトウ コレステ
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Abstract
Effects of dietary addition of some xenobiotics on the metabolism of α-tocopherol in rats were studied with special reference to cholesterol metabolism. Dietary xenobiotics including PCB, DDT, Chloretone, phenobarbital, etc. caused an increase in serum α-tocopherol and cholesterol. The effects of dietary PCB on serum and tissue levels of α-tocopherol were influenced with dietary protein and copper. The increases in serum α-tocopherol and cholesterol due to the chemicals were attributed to the increases in the fraction of high-density-lipoproteins (HDL). Dietary PCB and Chloretone caused an increase in apparent absorption of α-tocopherol. Dietary clofibrate depressed the increases in serum and tissue α-tocopherol, and serum cholesterol and also suppressed the increase in apparent absorption of α-tocopherol by Chloretone. These results suggest that the increase in serum cholesterol due to xenobiotics relates to the increase in serum and tissue α-tocopherol. As well as xenobiotics, feeding of cystine excess and histidine excess diets which are known to cause hypercholesterolemia also increased serum α-tocopherol.
Journal
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- VITAMINS
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VITAMINS 66 (1), 25-34, 1992
THE VITAMIN SOCIETY OF JAPAN
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Details 詳細情報について
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- CRID
- 1390001205833496960
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- NII Article ID
- 110002849127
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- NII Book ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL BIB ID
- 3762683
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed