アラキドン酸12-リポキシゲナーゼの生化学的ならびに分子生物学的研究

DOI Web Site 被引用文献2件

書誌事項

タイトル別名
  • Biochemical and Molecular Biological Studies of Arachidonate 12-Lipoxygenases
  • アラキドンサン 12 リポキシゲナーゼ ノ セイカガクテキ ナラビニ ブンシ

この論文をさがす

説明

Arachidonate 12-lipoxygenase is a dioxygenase which incorporates one molecule of oxygen into arachidonic acid and produces 12S-hydroperoxy-5, 8, 10, 14-eicosate-traenoic acid. The enzyme has been found in various tissues of many animal species. Two types of 12-lipoxygenase are distinguishable in terms of substrate specificity. The leukocyte-type enzyme is active not only with arachidonic acid and other C_<20> acids but also with C_<18> acids such as linoleic and linolenic acids. In contrast, the platelet-type enzyme is almost inactive with C_<18> acids. The two enzymes are also distinct in terms of immunogenicity, heat stability and reaction time course. Furthermore, the cDNAs for porcine leukocyte and human platelet 12-lipoxygenases do not cross-hybridize each other. The substrate specificity, immunogenicity, primary structure and genomic organization of porcine leukocyte 12-lipoxygenase are closer to those of rabbit reticulocyte 15-lipoxygenase than those of human platelet 12-lipoxygenase. The leukocyte-type enzyme has also been found in porcine pituitary, bovine trachea, canine brain, and human adrenal glomerulosa cells, but the platelet type enzyme has so far been found only in platelets of several animal species.

収録刊行物

  • ビタミン

    ビタミン 67 (1), 1-16, 1993

    公益社団法人 日本ビタミン学会

被引用文献 (2)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ