S021011 細胞頂端面の収縮性が成長する上皮組織の曲率に及ぼす影響 : リバージブル・ネットワーク・リコネクション・シミュレーションによる検討([S021]多細胞・組織への展開を目指した細胞工学)
書誌事項
- タイトル別名
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- S021011 Reversible Network Reconnection Simulation of Effects of Apical Contractility on Curvatures of Growing Epithelia
説明
A rapidly growing epithelial sheet during tissue morphogenesis typically shows a smooth and continuous curvature.However,given that cell divisions,which substantially perturb the local force balance,frequently and successively occur in an uncoordinated manner,it is not self-evident to explain how the tissue keeps a continuous curvature at large.In this study,we demonstrate that tangential contractile forces on the apical surface play a critical role in the maintenance of smooth curvatures in the epithelium and reduce irregular undulations caused by uncoordinated generation of local pushing force.Using a reversible network reconnection(RNR) model,which we previously developed to make numerical analyses highly reproducible even under rapid tissue-growth conditions,we performed simulations for morphodynamics to examine the effect of apical contractile forces on the continuity of curvatures.Interestingly,the presence of apical contractile forces suppressed irregular undulations not only on the apical side,but also on the basal surface.These results indicate that cellular contractile forces on the apical surface control not only the shape at a single cell level,but also at a tissue level as a result of emergent mechanical coordination.
収録刊行物
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- 年次大会
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年次大会 2013 (0), _S021011-1-_S021011-3, 2013
一般社団法人 日本機械学会
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詳細情報 詳細情報について
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- CRID
- 1390001205840853760
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- NII論文ID
- 110009933970
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- ISSN
- 24242667
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
