617 Mutual Effects of Cholesterol and Stretching Speed on Rupture of Phospholipid Bilayers under Stretching : Molecular Dynamics Simulation

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  • 617 コレステロールの含有率と引張速さの違いがリン脂質二重膜の破断に与える相互効果 : 分子動力学シミュレーション(GS2,21 バイオ・マイクロナノ,研究討論セッション)

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Molecular dynamics simulations of pure DPPC and DPPC/cholesterol bilayers under stretching with various stretching speeds were performed. The lower the stretching speed, the more ordered the DPPC molecules, which tendency was more prominent in the DPPC/cholesterol bilayer. The critical areal strain, where the rupture occurs, in the pure DPPC bilayer significantly increased with the increase of the stretching speed, whereas that in the DPPC/cholesterol bilayer did not. The difference of the process of the molecular orientation changes under stretching might cause the difference of the stretching speed effects on the critical areal strain.

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