書誌事項
- タイトル別名
-
- Stress Evaluation of Chondrocyte Cell by Using Multi-scale Finite Element Method and Smoothed Particle Hydrodynamics Method
抄録
<p>The morphology and function of articular cartilage tissue is regenerated through the metabolic activity of cells stimulated by the mechanical loading. In this study, a biphasic multi-scale analyses scheme is adopted for stress evaluation occurred in the chondrocyte cell. The dynamic-explicit finite element (FE) method was employed for the solid phase and the smoothed particle hydrodynamics (SPH) method was used for the fluid phase. A macro-scale 3D human knee joint FE model was constructed based on magnetic resonance (MR) cross sectional images. Further, we derived the Representative volume element (RVE) based on the Multiphoton microscopy (MPM) observation to build a micro-scale FE model of cartilage tissue. We characterized three layers in the articular cartilage tissue. Parameters of the visco-anisotropic hyperelastic constitutive law and SPH models were determined using experimental results. Biphasic multi-scale FE and SPH analyses were carried out under the maximum loading condition in the normal walking motion. As a result, large flow velocity was observed around chondrocyte in the surface layer. The highest hydrostatic and shear stress occurred on chondrocyte in the surface layer. Numerical results shows a good agreement with experimental results.</p>
収録刊行物
-
- M&M材料力学カンファレンス
-
M&M材料力学カンファレンス 2016 (0), GS-45-, 2016
一般社団法人 日本機械学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001205871493504
-
- NII論文ID
- 130007120296
-
- ISSN
- 24242845
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可