書誌事項
- タイトル別名
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- OS1-1-1 Multiscale Structural Instability Phenomena of a Lipid Bilayer Membrane Subject to Shear Flow
抄録
Lipid bilayer is a simplified model of a cell membrane. In medical or biotechnological situations, cells are often subject to shear flow in order to enhance molecular permeability or to get sorted. From a viewpoint of enhancing the intended effects, the shear rate is desired to be high enough. On the other hand, too high shear rate leads to the damage of cell membranes. However, it is extremely hard to observe the elementary process of the instability phenomena experimentally. Thus, we study the structural instability of a lipid bilayer in water subject to shear flow. We found from the coarse-grained molecular dynamics (CGMD) simulations that the shear-induced instabilities of a lipid bilayer membrane are multiscale phenomena. Shear-induced inclination of the lipid molecules causes the undulation structure after a buckling transition, which finally leads to the Kelvin-Helmholtz-like instability. We discuss the importance of capturing molecular discreteness and a higher level of structure simultaneously.
収録刊行物
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- マイクロ・ナノ工学シンポジウム
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マイクロ・ナノ工学シンポジウム 2012.4 (0), 119-120, 2012
一般社団法人 日本機械学会
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詳細情報 詳細情報について
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- CRID
- 1390001205902232320
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- NII論文ID
- 110009953421
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- ISSN
- 24329495
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可