1224 Observation of cancellous bone microstructure in regeneration process

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  • 1224 海綿骨再形成過程における微視組織構造の観察(G02-3 骨梁構造とリモデリング,G02 バイオエンジニアリング)

Abstract

Regeneration and remodeling processes of trabecular bone structure in cancellous bone defects are affected by various factors. Basic understanding of the bone regeneration mechanism will help us to design artificial joints, implants and scaffold microstructure for bone tissue regeneration. In this study, artificial defect was created in cancellous bone region of a rat distal femur, and a formation mechanism of trabecular structure in the defect was evaluated using X-ray μCT and microscopy. As a result, it was revealed that the directionality of defect did not directly influence on the formation of bone structure, while the defect shape have remarkable influence on the bone matrix formation.

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