31 細菌内毒素の活性部位リピドAの構造と合成

DOI

書誌事項

タイトル別名
  • 31 STRUCTURE AND SYNTHESIS OF LIPID A, THE ACTIVE PRINCIPLE OF BACTERIAL ENDOTOXIN

抄録

The lipophilic portion of bacterial lipopolysaccharide(LPS) is designated lipid A which is known to be responsible for most of the endotoxic activities of LPS. In the course of our synthetic study, we found that synthetic acyl disaccharide phosphates (4) corresponding to the proposed structure of lipid A showed certainly some of its typical biological activities. However, their potencies were significantly lower than those of natural samples. This prompted us to reinvestigate the chemical structure of natural lipid A. Thus, a homogeneous main component of E. coli, Re lipid A was isolated after chemical modification and its structure was elucidated as shown in 1 by combination of chemical method and the 2D-NMR technique. This was the first exact evidence for the acylation positions of the disaccharide backbone in the natural lipid A. The hitherto accepted structure (3) must be now revised. Synthesis of an acyl disaccharide diphosphate (2) based on our new structure is also being investigated.

収録刊行物

詳細情報 詳細情報について

  • CRID
    1390001206074074496
  • NII論文ID
    110006678388
  • DOI
    10.24496/tennenyuki.26.0_236
  • ISSN
    24331856
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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