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P-29 Chemical elucidation of a food poisoning affair of Pleurocybella porrigens
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- Suzuki Tomohiro
- Department of Bioscience, Graduate School of Science and Technology, Shizuoka University
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- Kawaguchi Takumi
- Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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- Amano Yuko
- Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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- Kobayashi Yuka
- Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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- Morita Tatsuya
- Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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- Nagai Kaoru
- Department of Epigenetic Medicine, Interdisciplinary Graduate School of Medicine and Engineering, Yamanashi University
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- Arai Nobutaka
- Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neuroscience
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- Kawagishi Hirokazu
- Department of Bioscience, Graduate School of Science and Technology, Shizuoka University:Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
Bibliographic Information
- Other Title
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- P-29 スギヒラタケ食中毒事件の化学的解明(ポスター発表の部)
Description
In autumn, 2004, 55 people got poisoned by eating an edible wild mushroom, Pleurocybella porrigens (Sugihiratake in Japanese) and 17 people among them died of acute encephalopathy. We found that mice died by injection of the wter-soluble extracts of the mushroom. We tried the isolation of the toxic principle(s) from the extracts. As a result, a lectin (PPL) and a glycoprotein were purified from the mushroom. PPL is a tetramer of identical subunits without S-S linkage. The lectin specifically bound N-acetylgalactosamine among monosacchrides tested. This lectin showed lethal toxicity against rats. In addition, a glycoprotein was isolated as a lethal toxin against mice and rats. The relation between these substances and acute encephalopathy is now being elucidated.
Journal
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- Symposium on the Chemistry of Natural Products, symposium papers
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Symposium on the Chemistry of Natural Products, symposium papers 48 (0), 325-330, 2006
Symposium on the Chemistry of Natural Products Steering Committee
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Details 詳細情報について
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- CRID
- 1390001206077381888
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- NII Article ID
- 110006682675
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- ISSN
- 24331856
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed