P-29 Chemical elucidation of a food poisoning affair of Pleurocybella porrigens

  • Suzuki Tomohiro
    Department of Bioscience, Graduate School of Science and Technology, Shizuoka University
  • Kawaguchi Takumi
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
  • Amano Yuko
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
  • Kobayashi Yuka
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
  • Morita Tatsuya
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
  • Nagai Kaoru
    Department of Epigenetic Medicine, Interdisciplinary Graduate School of Medicine and Engineering, Yamanashi University
  • Arai Nobutaka
    Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neuroscience
  • Kawagishi Hirokazu
    Department of Bioscience, Graduate School of Science and Technology, Shizuoka University:Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University

Bibliographic Information

Other Title
  • P-29 スギヒラタケ食中毒事件の化学的解明(ポスター発表の部)

Description

In autumn, 2004, 55 people got poisoned by eating an edible wild mushroom, Pleurocybella porrigens (Sugihiratake in Japanese) and 17 people among them died of acute encephalopathy. We found that mice died by injection of the wter-soluble extracts of the mushroom. We tried the isolation of the toxic principle(s) from the extracts. As a result, a lectin (PPL) and a glycoprotein were purified from the mushroom. PPL is a tetramer of identical subunits without S-S linkage. The lectin specifically bound N-acetylgalactosamine among monosacchrides tested. This lectin showed lethal toxicity against rats. In addition, a glycoprotein was isolated as a lethal toxin against mice and rats. The relation between these substances and acute encephalopathy is now being elucidated.

Journal

Details 詳細情報について

  • CRID
    1390001206077381888
  • NII Article ID
    110006682675
  • DOI
    10.24496/tennenyuki.48.0_325
  • ISSN
    24331856
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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