39 クロモプロテイン系エンジイン抗生物質の化学 : 常磁性を示す原理(口頭発表の部)
書誌事項
- タイトル別名
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- 39 Paramagnetic Chromoprotein Enediyne Antibiotic C-1027 : Chemical Mechanism
抄録
A number of extremely potent enediyne antitumor antibiotics have been isolated from culture filtrates of Streptomyces species. Although these antibiotics are believed to generate p-benzyne-type biradicals through cycloaromatization, no direct EPR measurements of carbon radical species generated from enediyne antibiotics have been reported. A chromoprotein antibiotic, C-1027, which is powder of a 1:1 complex composed of a carrier apoprotein and a DNA cleaving enediyne chromophore (1), shows a steady EPR spectrum at room temperature. Here, we characterize three paramagnetic species existing in C-1027 antibiotic by EPR spectroscopy: a phenyl radical (3), a radical pair between a peptide carbon radical and 3, and a peroxy radical. These radical species are supplied constantly by dynamic processes through hydrogen abstraction by p-benzyne type biradical (2) from apoprotein. The present results provide strong evidence for equilibration between 1 and 2, and a chemical mechanism of deterioration leading to self-inactivation of the C-1027 antibiotic.
収録刊行物
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- 天然有機化合物討論会講演要旨集
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天然有機化合物討論会講演要旨集 42 (0), 229-234, 2000
天然有機化合物討論会実行委員会
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詳細情報 詳細情報について
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- CRID
- 1390001206080248320
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- NII論文ID
- 110006681941
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- ISSN
- 24331856
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可