Antiinflammatory and Analgesic Activities of <i>Thesium chinense</i> Turcz Extracts and its Major Flavonoids, Kaempferol and Kaempferol-3-<i>O</i>-glucoside

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  • PARVEEN Zahida
    School of Life Sciences and Technology, Beijing Institute of Technology
  • DENG Yulin
    School of Life Sciences and Technology, Beijing Institute of Technology
  • SAEED Muhammad Khalid
    School of Life Sciences and Technology, Beijing Institute of Technology
  • DAI Rongji
    School of Life Sciences and Technology, Beijing Institute of Technology
  • AHAMAD Waqar
    School of Life Sciences and Technology, Beijing Institute of Technology
  • YU Yu Hong
    School of Life Sciences and Technology, Beijing Institute of Technology

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  • Antiinflammatory and analgesic activities of Thesium chinense Turcz extracts and its major flavonoids, kaempferol and kaempferol-3-O-glucoside

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Abstract

  The ethyl acetate, chloroform extracts, and the two flavonoids kaempferol 1 and kaempferol-3-O-glucoside 2 isolated from whole plants of Thesium chinense Turcz were investigated for their antiinflammatory and analgesic activities. For the antiinflammatory activity, carrageenan-induced hind paw edema and xylene-induced mouse ear edema models, and for the analgesic activity, the acetic acid-induced abdominal constriction test was used. The ethyl acetate extract and two flavonoids showed significant (p<0.05 and p<0.01) and dose-dependent antiinflammatory and analgesic activity. The chloroform extract was inactive in the assay.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 127 (8), 1275-1279, 2007-08-01

    The Pharmaceutical Society of Japan

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