Photosensing by Membrane-embedded Receptors and Its Application for the Life Scientists

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  • Sudo Yuki
    Division of Biological Science, Graduate School of Science, Nagoya University PRESTO, Japan Science and Technology Agency (JST)
  • Homma Michio
    Division of Biological Science, Graduate School of Science, Nagoya University

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  • 光受容タンパク質による微生物の光センシングの理解とその利用
  • ヒカリ ジュヨウ タンパクシツ ニ ヨル ビセイブツ ノ ヒカリ センシング ノ リカイ ト ソノ リヨウ

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Abstract

  Light is one of the most important energy sources and signals providing critical information to biological systems. The photoreceptor rhodopsin, which possesses retinal chromophore (vitamin A aldehyde) surrounded by seven transmembrane alpha-helices, is widely dispersed in prokaryotes and in eukaryotes. Although rhodopsin molecules work as distinctly different photoreceptors, they can be divided according to their two basic functions such as light-energy conversion and light-signal transduction. Thus rhodopsin molecules have great potential for controlling cellular activity by light. Indeed, a light-energy converter channel rhodopsin is used to control neural activity. From 2001, we have been working on various microbial sensory rhodopsins functioning as light-signal converters. In this review, we will introduce rhodopsin molecules from microbes, and will describe artificial and light-dependent protein expression system in Escherichia coli using Anabeana sensory rhodopsin (ASR). The newly developed tools would be widely useful for life scientists.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 132 (4), 407-416, 2012-04-01

    The Pharmaceutical Society of Japan

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