Mechanisms for Linking High Salt Intake to Vascular Tone: Role of Na<sup>+</sup> Pump and Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger Coupling

DOI Web Site Web Site 10 References Open Access
  • KITA Satomi
    Department of Pharmacology, Faculty of Medicine, Fukuoka University
  • IWAMOTO Takahiro
    Department of Pharmacology, Faculty of Medicine, Fukuoka University

Bibliographic Information

Other Title
  • 食塩負荷から血管トーヌス亢進へのメカニズム：Na<sup>+</sup>ポンプ・Na<sup>+</sup>/Ca<sup>2+</sup>交換体共役系の役割
  • 食塩負荷から血管トーヌス亢進へのメカニズム--Na[+]ポンプ・Na[+]/Ca[2+]交換体共役系の役割
  • ショクエン フカ カラ ケッカン トーヌス コウシン エ ノ メカニズム Na ポンプ Na Ca 2 コウカンタイ キョウヤクケイ ノ ヤクワリ

Search this article

Description

  Excessive salt intake is a major risk factor for hypertension. However, the underlying molecular relationship between salt and hypertension is not fully understood. Recently discovered cardiotonic steroids, such as endogenous ouabain and other steroids, have been proposed as candidate intermediaries. Plasma cardiotonic steroids are significantly elevated in patients with essential hypertension and in salt-dependent hypertensive animals. Generally, it is believed that cardiotonic steroids inhibit Na+ pump activity and lead to an increase in the cytosolic Na+ concentration. Cellular Na+ accumulation raises the cytosolic Ca2+ concentration through the involvement of Na+/Ca2+ exchanger type 1 (NCX1). In isolated arteries from α2 Na+ pump knockout mice (α2+/−), myogenic tone is increased, and NCX inhibitor normalizes the elevated myogenic tone in α2+/− arteries. The NCX inhibitor lowers arterial blood pressure in salt-dependent hypertensive rats but not in other types of hypertensive rats or in normotensive rats. Furthermore, smooth muscle-specific NCX1 transgenic mice are hypersensitive to salt, whereas mice with smooth muscle-specific knockout of NCX1 (NCX1SM−/−) have low salt sensitivity. These results suggest that functional coupling between the vascular α2 Na+ pump and NCX1 is a critical molecular mechanism for salt-induced blood pressure elevation.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 130 (11), 1399-1405, 2010-11-01

    The Pharmaceutical Society of Japan

References(10)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top